Open AccessThe effect of the management with fresh frozen plasma on the outcome of patients with acute organophosphate poisoning
Author(s) -
S.I. Saad,
Monira Taha Ismail,
Rania Hashish,
Rehab I. Abdel-Karim,
Mohamed Abdel Aal,
Gouda Ellabban
Publication year - 2017
Publication title -
international journal of surgery and medicine/international journal of surgery and medicine
Language(s) - English
Resource type - Journals
eISSN - 2367-7414
pISSN - 2367-699X
DOI - 10.5455/ijsm.fresh-frozen-plasma-organophosphate-poisoning
Subject(s) - medicine , organophosphate poisoning , fresh frozen plasma , organophosphate , outcome (game theory) , emergency medicine , pesticide , platelet , agronomy , biology , mathematics , mathematical economics
Background: Organophosphate (OP) poisoning is an important reason for hospitals and intensive care units admission in the developing countries. OP poisoning patients are classically treated with atropine and oximes, these methods are sometimes shown to be of limited benefit.\udObjective: Assessment of the effectiveness of the management with fresh frozen plasma (FFP) in improving the outcome of patients with acute OP poisoning.\udPatient and Methods: A randomized clinical trial study was conducted upon 70 acute OP poisoning patients that were referred to the Emergency Department, Suez Canal University Hospital, Ismailia, Egypt. These patients were randomly divided into two groups (35 each); Control group: Treated with the traditional management protocol of OP (atropine and oximes). FFP group: Treated with the traditional management protocol of OP plus FFP.\udResults: No significant difference was found in cholinesterase level on admission between both groups, Serum cholinesterase level in the FFP group significantly increased after an hour of FFP infusion (2.48 iu/ml vs. 10.36 iu/ml