Open AccessThe Regulation of Hypoxia Inducible Factor (HIF)1α Expression by Quercetin: an In Silico Study
Author(s) -
Sri Puji Astuti Wahyuningsih,
Firli Rahmah Primula Dewi,
Amy Saik Yi Hsan,
Looi Mee Lee,
Vuanghao Lim,
Lionel Lian Aun In,
Tau Chuan Ling,
Sephia Tiara Marviella
Publication year - 2022
Publication title -
acta informatica medica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.267
H-Index - 20
eISSN - 1986-5988
pISSN - 0353-8109
DOI - 10.5455/aim.2022.30.96-99
Subject(s) - in silico , quercetin , transcription factor , chemistry , docking (animal) , ubiquitin , hypoxia inducible factor 1 , biochemistry , medicine , gene , nursing , antioxidant
Cancer disease is a growing health problem in developing and developed countries. Hypoxia-inducible factor-1a (HIF1α) is a transcription factor responsible for expressing several proteins involved in angiogenesis. Quercetin can suppress HIF1α expression due to the inhibition of protein synthesis. However, to date, the study exploring the potential of quercetin in repressing HIF1α through its degradation mechanism has never been done. An in silico study is needed as a preliminary study to understand the mechanism underlining this possibility.