Intra-Abdominal Metabolism and Blood Flow During Abdominal Hypertension - A Porcine Pilot Study Under Intravenous Anaesthesia

Objective: To study the splanchnic metabolism and intestinal circulation in a porcine model with increased abdominal pressure.Methods: In an experimental porcine study, performed under intravenous anaesthesia, five animals were subjected to gradually increasing intra-abdominal pressure (15 mmHg, 25 mmHg, and 35 mmHg) with pneumoperitoneum. Microdialysis and laser Doppler were the main outcome methods for monitoring the metabolic and circulatory changes.Results: During stable anaesthesia and gradually increasing intra-abdominal pressure obtained by CO2-pneumoperitoneum, blood flow (microcirculation) was deprived and moderate signs of impaired splanchnic metabolism were recorded.Conclusions: The model appears usable for studies of splanchnic metabolic consequences of intra-abdominal hypertension. [Arch Clin Exp Surg 2013; 2(3.000): 176-185