Open AccessBarium Enema in the Diagnosis of Hirschsprung's Disease: A Comparison with Rectal Biopsy
Author(s) -
Mohammad Abbas,
Arshad Rashid,
Asim Rafiq Laharwal,
Ajaz Ahmad Wani,
Shabir Ahmad Dar,
Manzoor Ahamad Chalkoo,
Showkat Majeed Kakroo
Publication year - 2013
Publication title -
archives of clinical and experimental surgery
Language(s) - English
Resource type - Journals
ISSN - 2146-8133
DOI - 10.5455/aces.20120703031135
Subject(s) - barium enema , medicine , hirschsprung's disease , enema , biopsy , general surgery , radiology , gastroenterology , disease , colonoscopy , colorectal cancer , cancer
Aim: The aim of the present study was to compare the diagnostic accuracy of a barium enema in Hirschsprung's disease with respect to a rectal biopsy.Materials And Methods: This study was conducted on 60 consecutive patients of clinically suspected cases of Hirschsprung's disease admitted to a tertiary care hospital in Kashmir over a period of three and a half years. All the patients were subjected to a barium enema and a full-thickness rectal biopsy. Results: The mean age was 3.5 + 0.5 years. A rectal biopsy revealed absence of ganglion cells in 36 (60%) patients, absence of ganglion cells with nerve hypertrophy in 4 (6.66%) patients and ruled out Hirschsprung's disease in 20 (33.33%) patients. A barium enema was compatible with Hirschsprung's disease in 20 (33.33%), suggestive in 14 (23.33%) and unremarkable in 26 (43.33%) patients. A barium enema had a diagnostic accuracy of 76.67% with a positive predictive value of 88.23%, a negative predictive value of 61.53%, specificity of 80% and a sensitivity of 75%, and a rectal biopsy had a diagnostic accuracy of 100% (P value < 0.0001).Conclusion: Barium enema is a valuable diagnostic tool for the diagnosis of patients with Hirschsprung's disease. We recommend a barium enema as a routine initial workup in the management of patients of suspected Hirschsprung's disease. [Arch Clin Exp Surg 2013; 2(4.000): 224-228