Open AccessASSOCIATION OF CRP AND D-DIMER WITH CT SEVERITY SCORING IN COVID-19 PATIENTS
Author(s) -
Sunil Patel,
Shital Adhikari,
Basanta Gauli,
Madhur Dev Bhattarai,
Bigyan Paudel,
Deepak Adhikari,
Sailesh Gurung,
Pratik Wagley,
Niraj Puri,
Bibek Regmi
Publication year - 2022
Publication title -
journal of chitwan medical college
Language(s) - English
Resource type - Journals
ISSN - 2091-2412
DOI - 10.54530/jcmc.538
Subject(s) - medicine , d dimer , covid-19 , pneumonia , c reactive protein , severity of illness , computed tomography , gastroenterology , disease , surgery , infectious disease (medical specialty) , inflammation
Background: Corona virus disease 2019 (COVID-19) has become a global public health issue with significant impacts upon the healthcare delivery systems. Previous studies have consistently found elevated levels of C-Reactive Protein and D-dimer with disease severity. In this study, we aimed to investigate the relationship between C-Reactive Protein, D-dimer level and Computed Tomography severity score in patients with SARS-COV-2 pneumonia.Methods: Our study included 76 patients with COVID-19, admitted in COVID Unit of Chitwan Medical College and Teaching Hospital from June 2020 to December 2020. We included COVID-19 cases confirmed by a RT-PCR test and those undergoing High resolution Computed Tomography of chest and having C-Reactive Protein and D-dimer levels done on admission. A semi-quantitative CT score was calculated based on the extent of lobar involvement (0:0%; 1, 75%; range 0–5; global score 0–25.Results: Overall the median CTSS was 15. Mild, moderate and severe CT severity scoring was reported in 5.3%, 60.5% and 34.2% respectively and D-dimer progressively increased across the CTSS severity groups. The difference was significant for CRP, P = 0.007 but not for D-dimer, P = 0.42. Moreover, higher CTSS scores were significantly associated with higher ICU stay, lower recovery rate and higher O2 requirement at discharge.Conclusions: Radiological severity of COVID-19 pneumonia has significant association with elevated C-Reactive Protein level but not with D-dimer level and other routine laboratory parameters.