Open AccessThe Effect of Methanolic Extract of Corn Silk in Gentamicin Induced Acute Renal Injury in Rats Model
Author(s) -
Ayesha Amjad,
Bahisht Rizwan,
Shaista Jabeen
Publication year - 2022
Publication title -
pakistan biomedical journal
Language(s) - English
Resource type - Journals
eISSN - 2709-2798
pISSN - 2709-278X
DOI - 10.54393/pbmj.v5i1.259
Subject(s) - creatinine , gentamicin , urea , chemistry , medicine , pharmacology , traditional medicine , biochemistry , antibiotics
Corn Silk is a worthwhile herb that possesses health promoting nutrients including flavonoids. The bioactive compounds in Corn Silk that are beneficial for health includes vitamins, carbohydrates, magnesium, proteins, calcium, sodium and magnesium salts, alkaloids, steroids and volatile salts, potassium, flavonoids and many other phenolic compounds. Maysin is one of the flavonoids in Corn Silk. The present study highlights the therapeutic effects of Corn Silk in Acute Renal Injury. This study was designed to observe the effect of methanol extract of corn silk on Gentamicin induced acute renal injury. 18 rats were divided into 3 groups each containing 6 rats. Acute renal injury was induced in all 18 rats by injecting Gentamicin (100mg/kg/BW) intra-peritoneal for 7 days. After the induction of Acute Renal Injury (Serum Urea ≥ 10-50 mg/dl, Creatinine ≥ 0.5-1.4), the treatment was started. The first Group (G0) received isotonic saline (0.1ml/kg/BW), 2nd group (G1) received Corn Silk extract (200mg/kg/BW) orally, and 3rd group (G2) received Corn Silk extract (300mg/kg/BW) orally. This treatment was given to rats for 21 days. During this study body weight of each rat was also measured. The assessment of different biochemical parameters such as Serum Urea and Creatinine level was done. The results showed that Corn silk extract helped in the treatment of acute renal injury by reducing the elevated renal parameters. Moreover, the reduction in weight was also observed.