Open AccessEffect of Trachyspermum ammi essential oil, fractions and its derivatives on resistant fungal Strains
Author(s) -
Naila Iram,
Muhammad Asif Hanif,
Haq Nawaz Bhatti,
Muhammad Shahid
Publication year - 2021
Publication title -
pakistan biomedical journal
Language(s) - English
Resource type - Journals
eISSN - 2709-2798
pISSN - 2709-278X
DOI - 10.54393/pbmj.v4i2.153
Subject(s) - sabinene , antimicrobial , antifungal , essential oil , ammi , myrcene , traditional medicine , chemistry , biology , microbiology and biotechnology , food science , limonene , medicine , biochemistry , gene–environment interaction , gene , genotype
Persistentantimicrobial drugs treatmenthas resulted in antimicrobial resistance in fungi. There is always a gap for newer antifungal agent. As fungi are associated with multiple health risks in humans and many diseases in crops as well.Objective: To find alternate natural antimicrobial agent as compared to the synthetic one. Method:Essential oil of Trachyspermumammi was isolated, fractionated, and subjected to GC-MS analysis. Components from fractions were derivatized to check their antimicrobial potential against fungal resistant strains. Results:Analysis showed γ -terpinene (39%), α-phellandrene (1.3%), α-pinene (0.5%), Sabinene (0.15%), β-pinene (4.40%), β-myrcene (1.14%), O-cymene (15.78%), p-cymefne (38.78%), and other components were less than 1%. Fractional components were derivatised and their antifungal action was studied. Conclusion: Ajwain oil components found to be good against resistant fungal strains. While some derivatives showed more and some less antimicrobial action.