Open AccessPlatelet-rich Blood Derivatives for Tendon Regeneration
Author(s) -
Raquel CostaAlmeida,
Pedro S. Babo,
Rui L. Reis,
Manuela E. Gomes
Publication year - 2020
Publication title -
journal of the american academy of orthopaedic surgeons
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.343
H-Index - 111
eISSN - 1095-8762
pISSN - 1067-151X
DOI - 10.5435/jaaos-d-18-00638
Subject(s) - medicine , regeneration (biology) , tendon , platelet rich plasma , homeostasis , platelet , intensive care medicine , bioinformatics , surgery , microbiology and biotechnology , biology
Tendon injuries constitute a significant healthcare problem with variable clinical outcomes. The complex interplay of tissue homeostasis, degeneration, repair, and regeneration makes the development of successful delivery therapeutic strategies challenging. Platelet-rich hemoderivatives, a source of supra-physiologic concentrations of human therapeutic factors, are a promising application to treat tendon injuries from the perspective of tendon tissue engineering, although the outcomes remain controversial.