Open AccessEstudos termoanalíticos da cimetidina e dos complexos com os íons Mn(II) Co(II) E Ni(II)
Author(s) -
Ana Carolina Mendes Hacke,
Fernanda Moreira,
Egon Schnitzler,
Neiva Deliberali Rosso
Publication year - 2013
Publication title -
semina. ciências exatas e tecnológicas
Language(s) - English
Resource type - Journals
eISSN - 1679-0375
pISSN - 1676-5451
DOI - 10.5433/1679-0375.2013v34n2p229
Subject(s) - cimetidine , chemistry , thermogravimetry , decomposition , thermal stability , thermal decomposition , metal , inorganic chemistry , pyrolytic carbon , differential thermal analysis , medicinal chemistry , nuclear chemistry , pyrolysis , organic chemistry , medicine , physics , diffraction , optics
Cimetidine is an important hydrogen histamine receptor and can coordinate metal ions in blood plasma. The stability of cimetidine and its complexes with Mn(II), Co(II) and Ni(II) was evaluated by studies of thermogravimetry (TG) and differential thermal analysis (DTA). Cimetidine was thermally stable up to near 190 °C and above this temperature the thermal decomposition occurred in two stages. Complexes of [Mn(HCm)2]Cl2, [Co(Cm)2]Cl2 and [Ni(Cm)2]Cl2 showed a similar behavior. The pyrolytic decomposition occurred in two stages at temperatures above 250 oC. A residue for each complex was detected at the end of the decomposition process. This probably corresponds to the respective metal oxide