Open AccessAvaliação do polimorfismo genético pvuII do receptor de lipoproteína de baixa densidade (RLDL) em pacientes com lúpus eritematoso sistêmico
Author(s) -
Juliana Elisa Lima,
Marcell Alysson Batisi Lozovoy,
Daniela Frizon Alfieri,
Francieli Delongui,
Ana Paula Kallaur,
Edna Maria Vissoci Reiche,
Elaine Regina Delicato de Almeida
Publication year - 2014
Publication title -
semina. ciências biológicas e da saúde
Language(s) - English
Resource type - Journals
eISSN - 1679-0367
pISSN - 1676-5435
DOI - 10.5433/1679-0367.2015v36n1suplp109
Subject(s) - microbiology and biotechnology , medicine , biology
Systemic lupus erythematosus (SLE) is a chronic inflammatory disease of connective tissue related to changes in lipid profile and lipoprotein metabolism. Studies show that the genetic polymorphism of PvuII low density lipoprotein receptor (LDLR) is associated with different concentrations of low density lipoprotein (LDL) in general population. The present study evaluated the genetic polymorphism of PvuII LDLR and lipid profile in patients with SLE in southern Brazilian population. We included 72 patients with SLE and 154 blood donors. In assessing the lipid profile, SLE patients had elevated serum triglycerides (TG) levels compared with the control group (p 0.05). Patients with SLE and P1P1 genotype tended to have higher levels of TG compared with patients with SLE and P1P2 + P2P2 genotype (p = 0.0687). We conclude that genetic polymorphism may contribute to increased cardiovascular risk, however, the complexity of genetic components and disease evaluated should be taken into consideration. Further investigations are needed for other genes that may be involved in altering the lipid profile in this population