Open AccessRadiomic assessment of the progression of acoustic neuroma after gamma knife stereotactic radiosurgery
Author(s) -
G. Narayanasamy,
Geoffrey Zhang,
Eric Siegel,
G.W. Campbell,
Eduardo G. Moros,
Edvaldo Galhardo,
Steven Morrill,
John D. Day,
José Peñagarícano
Publication year - 2019
Publication title -
journal of solid tumors
Language(s) - English
Resource type - Journals
eISSN - 1925-4075
pISSN - 1925-4067
DOI - 10.5430/jst.v9n2p1
Subject(s) - radiosurgery , medicine , acoustic neuroma , univariate analysis , nuclear medicine , receiver operating characteristic , univariate , magnetic resonance imaging , gamma knife , neuroma , radiology , audiology , surgery , multivariate analysis , mathematics , multivariate statistics , radiation therapy , statistics
The aim of this study was to determine whether radiomic features measured at baseline in Magnetic Resonance images (MRI) of acoustic neuromas (AN) can predict Gamma Knife (GK) treatment outcome.Methods: The study was conducted on pre- and post-GK MRI-T2 scans of 32 patients with AN who underwent stereotactic radiosurgery (SRS) for 12 Gy dose. Radiomic features extracted include Intensity, Fractals, Laplacian of Gaussian and textural Co-Occurrence, Run-length (RL), Size Zone, and Neighborhood Gray-Tone Difference matrices (NGTDM) features. Subjects were classified as treatment failures (TF) if tumor volume increased > 10%. Pre- and post-SRS audiology reports were utilized in hearing evaluation.Results: Fifteen subjects (47%) qualified as TFs. In univariate receiver operating characteristic (ROC) analysis, two radiomicfeatures, complexity in NGTDM and run percentage in RL, displayed areas under curves of > 0.65.Conclusion: This initial radiomic study establishes features that illustrates the prognostic ability of the SRS treatment in acousticneuroma. Hearing preservation was achieved in a majority of acoustic neuroma patients treated in Gamma Knife.