Open AccessCentral nervous system penetration and efficacy of targeted therapies used in non-small cell lung cancer and melanoma with brain metastases
Author(s) -
Sidra Khalid,
Aariez Khalid,
Abdo Haddad,
Timothy Spiro,
Hamed Daw
Publication year - 2018
Publication title -
journal of solid tumors
Language(s) - English
Resource type - Journals
eISSN - 1925-4075
pISSN - 1925-4067
DOI - 10.5430/jst.v8n2p13
Subject(s) - medicine , melanoma , central nervous system , lung cancer , clinical trial , targeted therapy , oncology , clinical efficacy , cancer , cancer research
Recently, many targeted therapies have been approved for treating brain metastases in non-small cell lung cancer and melanoma patients. In this article, the targeted therapies and their mechanism of action will be reviewed. It will highlight the central nervous system penetration of the targeted therapies. The article will also relate the efficacy of these drugs as seen in clinical trials, which would help guide clinicians when managing these patients.