Open AccessCorrelation between Campanacci’s radiological classification of giant cell tumor of bone and expression of Cyclin D1 and PCNA
Author(s) -
Eréndira Estrada-Villaseñor,
Hidalgo Bravo Alberto,
Cindy Bandala,
Paloma De la Garza-Montaño,
Reyes Medixieli,
Pichardo Bahena Raúl,
EA Delgado-Cedillo,
LM Linares-González,
Genaro Rico-Martínez
Publication year - 2017
Publication title -
journal of solid tumors
Language(s) - English
Resource type - Journals
eISSN - 1925-4075
pISSN - 1925-4067
DOI - 10.5430/jst.v7n1p47
Subject(s) - proliferating cell nuclear antigen , cyclin d1 , immunohistochemistry , radiological weapon , medicine , cyclin , osteosarcoma , pathology , cell cycle , radiology , cancer
Giant cell tumor of bone is considered by his behavior a benign but aggressive neoplasm. The objective of our study was to determine if there is a correlation between the Campanacci’s radiological classification of giant cell tumors of bone and the expression by immunohistochemistry of Cyclin D1 and proliferation cell nuclear antibody (PCNA). A retrospective and descriptive study was made. In total, there were 27 cases. All cases showed Cyclin D1 and PCNA positivity. Rho Spearman for Campanacci and Cyclin D1 expression was 0.06 and for Campanacci and PCNA was 0.418. We conclude that there is a positive correlation between PCNA expression in giant cell tumors of Bone and the Campanacci’s radiological classification II and III, butCyclin D1 expression was no related with radiologic features.