Open AccessHistiocytic/dendritic cell transformation of indolent B-cell neoplasms: Clinical laboratory evidence of lineage conversion in hematolymphoid malignancies
Author(s) -
Endi Wang
Publication year - 2012
Publication title -
journal of hematological malignancies
Language(s) - English
Resource type - Journals
eISSN - 1925-4032
pISSN - 1925-4024
DOI - 10.5430/jhm.v2n1p1
Subject(s) - lineage (genetic) , immunophenotyping , biology , cell lineage , progenitor cell , haematopoiesis , cell of origin , lineage markers , histiocyte , dendritic cell , pathology , immunology , stem cell , cell , cellular differentiation , microbiology and biotechnology , medicine , genetics , flow cytometry , antigen , gene
It is well known that pluripotent progenitors of normal hematopoietic cells can differentiate into cell lineages that are distinct in morphology, immunophenotype and biological function [1]. The conventional concept holds that once a hematopoietic progenitor is committed to a given lineage, its fate is sealed and irreversible. This phenomenon of lineage commitment has also been universally observed in hematolymphoid neoplasms in the past.