Histiocytic/dendritic cell transformation of indolent B-cell neoplasms: Clinical laboratory evidence of lineage conversion in hematolymphoid malignancies | Zendy

Endi Wang | Zendy

Open Access

Histiocytic/dendritic cell transformation of indolent B-cell neoplasms: Clinical laboratory evidence of lineage conversion in hematolymphoid malignancies

Author(s) -

Endi Wang

Publication year - 2012

Publication title -

journal of hematological malignancies

Language(s) - English

Resource type - Journals

eISSN - 1925-4032

pISSN - 1925-4024

DOI - 10.5430/jhm.v2n1p1

Subject(s) - lineage (genetic) , immunophenotyping , biology , cell lineage , progenitor cell , haematopoiesis , cell of origin , lineage markers , histiocyte , dendritic cell , pathology , immunology , stem cell , cell , cellular differentiation , microbiology and biotechnology , medicine , genetics , flow cytometry , antigen , gene

It is well known that pluripotent progenitors of normal hematopoietic cells can differentiate into cell lineages that are distinct in morphology, immunophenotype and biological function ^[1]. The conventional concept holds that once a hematopoietic progenitor is committed to a given lineage, its fate is sealed and irreversible. This phenomenon of lineage commitment has also been universally observed in hematolymphoid neoplasms in the past.

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