Open AccessSerological and genotyping study of rare cis-AB01/O01 in the area of Inner Mongolia - with a case report
Author(s) -
ChunHai Wang,
Wenmei Wang,
HuaLiang Huang
Publication year - 2020
Publication title -
discussion of clinical cases
Language(s) - English
Resource type - Journals
eISSN - 2375-8449
pISSN - 2375-8473
DOI - 10.5430/dcc.v6n3p4
Subject(s) - abo blood group system , genotyping , allele , genetics , biology , serology , chromosome , gene , genotype , antibody
The antigen gene of ABO blood group system, called ABO, is located on human chromosome 9, with a total length of 19.5 kb. It is the first blood group system found by human beings.[1] ABO blood group subtypes are formed by ABO genovariation, i.e., gene A variation for A subtype, gene B variation for B subtype and gene O variation for new O alleles. ABO subtypes contain A3, Ax, Ael, Aw, Am, B3, Bx, Bel, Bw, cis-AB, B (A). Generally, an individual with AB blood group has an A allele on one chromosome, with B allele on its paired chromosome. This phenomenon is called trans-AB. However, cis-AB is a unique ABO phenotype that A and B alleles are located on the same chromosome, so that it can be inherited by the next generation.[2] This special mode of inheritance often causes a discrepancy of ABO blood grouping and then reduces the effectiveness and safety of blood transfusion.Therefore, to accurately identify the blood group of cis-AB is a precondition for the safety of blood transfusion.[3] The serological and genotyping analysis on a case of cis-AB patient in our hospital is reported as follows.