Open AccessDolutegravir induced sub-acute hepatic failure in HIV positive treatment naïve man in Botswana
Author(s) -
Godfrey Mutashambara Rwegerera,
Munashe Rimbi,
Vimbai Mudhina,
Marang Tiny Simone,
Moranodi Sefo,
Bofelo Segona
Publication year - 2019
Publication title -
case reports in internal medicine
Language(s) - English
Resource type - Journals
eISSN - 2332-7251
pISSN - 2332-7243
DOI - 10.5430/crim.v6n4p5
Subject(s) - dolutegravir , medicine , regimen , human immunodeficiency virus (hiv) , acute hepatic failure , hepatic dysfunction , antiretroviral therapy , gastroenterology , pediatrics , liver failure , viral load , immunology
Dolutegravir associated hepatic failure has rarely been reported. Hepatic failure can occur either acutely or after few weeks as it happened in our patient. We report a case of 61 years old HIV-positive treatment naïve patient who started experiencing features of hepatic injury one month after starting Dolutegravir-based regimen. Patient presented late with overt hepatic failure. We emphasize the importance of close monitoring both at initiation and long-term so as identify patients with early hepatic injury and limit fatal outcomes which are potentially avoidable.