Open AccessVasopressin-induced hyponatremia in a patient with pulmonary hypertension and right heart failure treated for septic shock
Author(s) -
Andrew C. Peters,
Yevgeniy Brailovsky,
Vladimir Lakhter,
Paul Forfia
Publication year - 2018
Publication title -
case reports in internal medicine
Language(s) - English
Resource type - Journals
eISSN - 2332-7251
pISSN - 2332-7243
DOI - 10.5430/crim.v5n3p36
Subject(s) - vasopressin , hyponatremia , discontinuation , medicine , septic shock , shock (circulatory) , vasodilation , heart failure , copeptin , free water clearance , cardiology , sepsis , anesthesia
We report a case of a 55-year-old woman who developed hyponatremia after the initiation of exogenous vasopressin to treat vasodilatory shock. Discontinuation of exogenous vasopressin therapy, without any other changes in medical therapy or the patient’s condition, led to a rapid correction in the serum sodium level along with a marked increase in urine output. Increased free water retention due to exogenous vasopressin administration may have contributed to hyponatremia in this patient. This case illustrates the potential for vasopressin to have potent and unintended renal and electrolyte effects in patients treated for vasodilatory shock.