Open AccessIntravascular large B cell lymphoma limited in renal glomaruli: A case presented as nephrotic syndrome
Author(s) -
Yingxue Cao,
Zhonghua Sun,
Liang Wang,
Jia Hua,
Shaojun Liu,
ChuanMing Hao
Publication year - 2017
Publication title -
case reports in internal medicine
Language(s) - English
Resource type - Journals
eISSN - 2332-7251
pISSN - 2332-7243
DOI - 10.5430/crim.v4n2p45
Subject(s) - intravascular large b cell lymphoma , pathology , nephrotic syndrome , lymphoma , medicine , renal biopsy , immunohistochemistry , infiltration (hvac) , lumen (anatomy) , cd20 , biopsy , physics , thermodynamics
Intravascular large B cell lymphoma (IVLBCL) is a rare type of non-Hodgkin lymphoma, characterized by selective proliferation of B cells within the lumens of small vessels. We report a case of IVLBCL with the invaded B cells limited in the lumen of glomerular capillary loops. The patient presented with nephrotic syndrome. Histological examination of renal biopsy specimens showed infiltration of neoplastic cells limited in glomerular capillary loops, accompanied by diffuse foot process effacement only in those capillary loops with the infiltrative cells. Immunohistochemistry shows that the infiltrative cells were positive for bcl-2, bcl-6, CD20, MUM1 and ki-67, consistent with atypical cells deriving from B cells. Unfortunately, the patient refused the further treatment and died soon after the diagnosis.