Open AccessAcute ophthalmoplegia without ataxia associated with anti-GQ1b antibody in a Chinese Gentleman
Author(s) -
Helen Lk Yip,
MC Kwan,
WK Cheng,
WY Lau
Publication year - 2016
Publication title -
case reports in internal medicine
Language(s) - English
Resource type - Journals
eISSN - 2332-7251
pISSN - 2332-7243
DOI - 10.5430/crim.v3n3p55
Subject(s) - ataxia , medicine , external ophthalmoplegia , antibody , miller fisher syndrome , guillain barre syndrome , weakness , pediatrics , immunology , surgery , biochemistry , chemistry , psychiatry , mitochondrial dna , gene
Miller Fisher first described three patients who suffered from acute neurological illness characterized by ophthalmoplegia, areflexia and ataxia. It is considered to be a subtype of Guillain Barre Syndrome. While another subtype of GBS without ataxia was first described by Chiba et al. and is associated with isolated acute ophthalmoplegia with raised anti-GQ1b Immunoglobulin G (IgG) antibody in early phase of illness. We report a Chinese patient who presented with acute ophthalmoplegia without ataxia nor limb weakness with strongly positive anti-GQ1b IgG antibody. His neurological symptoms improved after a course of intravenous immunoglobulin (IVIg) therapy.