Open AccessGestational Diabetes Mellitus a Dysfunctional Metabolic State-A Perspective
Author(s) -
Dhastagir Sultan Sheriff,
AUTHOR_ID
Publication year - 2019
Publication title -
series of endocrinology, diabetes and metabolism
Language(s) - English
Resource type - Journals
ISSN - 2768-413X
DOI - 10.54178/jsedmv1i2001
Subject(s) - gestational diabetes , insulin resistance , endocrinology , medicine , diabetes mellitus , insulin , fetus , glucose homeostasis , dysfunctional family , pregnancy , gestation , biology , clinical psychology , genetics
Pregnancy is considered as a test for beta cell reserve. If there is a good function, insulin resistance will overcome. If not, gestational diabetes will occur. Insulin resistance (IR) present in normal pregnancy is required to provide nutrients to the growing fetus. There is a rapid increase of insulin in such an insulin resistant state. The possibility of lipid deposition in muscle fibers (intramyocellular) could be one of the possible mechanism of IR in gestational diabetes mellitus (GDM). The poor response of insulin release, possible fat deposition in the skeletal muscle or ectopic fat deposition may cause dysfunctional homeostasis in GDM. This will definitely influence the fine tuning of metabolic machinery of a growing fetus. Children born with such subtle metabolic state will probably be more prone to glucose intolerance and ectopic lipid deposition. The finding that children born to GDM mothers are prone to glucose intolerance may be an eye-opener to monitor such children for beta cell function.