An efficient linkage analysis strategy for autosomal dominant polycystic kidney disease | Zendy

Tamehito Onoe | Zendy; Tadashi Konoshita | Zendy; Kyoko Miyagi | Zendy; Kazunori Yamada | Zendy; Hisao Mutoh | Zendy; Ichiro Koni | Zendy; Hideki Nomura | Zendy

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An efficient linkage analysis strategy for autosomal dominant polycystic kidney disease

Author(s) -

Tamehito Onoe,

Tadashi Konoshita,

Kyoko Miyagi,

Kazunori Yamada,

Hisao Mutoh,

Ichiro Koni,

Hideki Nomura

Publication year - 2003

Publication title -

clinical nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.314

H-Index - 75

ISSN - 0301-0430

DOI - 10.5414/cnp59406

Subject(s) - pkd1 , autosomal dominant polycystic kidney disease , loss of heterozygosity , genetic linkage , microsatellite , genetics , genotyping , genotype , population , biology , medicine , allele , kidney , gene , environmental health

Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common inherited renal disorders in the world. Mutations in PKD1 are responsible for 80-95% of all autosomal dominant polycystic kidney disease (ADPKD). Although the need for linkage analysis of ADPKD is decreasing after the success of mutation detection at whole exons of PKD1, linkage analysis still has some advantages in detecting non-PKD1 families, thereby avoiding hopeless mutation analysis.

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