Lessons from History: Association of Porphyromonas Gingivalis (a Major Periodontopathic Bacteria) in Alzheimer’s Disease Patients

Alzheimer’s disease (AD), a fatal neurodegenerative condition that affects the elderly, is a serious health problem for geriatric subjects worldwide. AD incidence increases significantly with age. It is almost 50% common in 85 -yearolds. [1] AD prevalence will rise as the population grows older and lives spans increase. It is estimated that around 14 million people will be affected by AD in the next 50 years. Switching to newer treatments can help reduce the incidence of AD. These treatment options can be effective against potential risk factors and delay the onset. What is the role of periodontitis in Alzheimer’s disease? This work aims to do a systematic, integrative review on published literature to evaluate if there is a link between Porphyromonas gumivalis (P. gingivalis), and Alzheimer’s. Part of (?) Part of (?) P. gingivalis could serve as a therapeutic target for patients suffering from Alzheimer’s disease. It also help s to reduce the severity and incidence of the condition. Patients with Alzheimer’s disease could benefit from preventive dental care and the inhibition of neurotoxicity by P. gingivalis.