Open AccessASSESSMENT OF OXIDATIVE STRESS AND INFLAMMATORY MARKERS OF MEDICAL IMPORTANCE IN ORAL SQUAMOUS CELL CARCINOMA
Author(s) -
Seema Butt,
Umaima Abbas,
Ainan Arshad,
Barzan Ahmad,
Aqsa Ashraf,
Muhammad Haseeb,
Arif Nazir Butt,
MA Rana,
MM Hafeez
Publication year - 2022
Publication title -
biological and clinical sciences research journal
Language(s) - English
Resource type - Journals
eISSN - 2958-4728
pISSN - 2708-2261
DOI - 10.54112/bcsrj.v2022i1.91
Subject(s) - oxidative stress , malondialdehyde , medicine , malignancy , basal cell , cancer , reactive oxygen species , gastroenterology , pathology , oncology , biology , biochemistry
There is an increased prevalence of Oral squamous cell carcinoma (OSCC), and it is a well-known human malignant cancer.Oxidative stress markersare helpful in diagnosis andto assess the progression malignancy. The current analysis aimed to determine the altered levels of reactive oxygen species and inflammatory markers in oral squamous cell carcinoma. This research was conducted by the general pathology department of Institute of dentistry, CMH Lahore,from September 17, 2021, to January 17, 2022. Total of sixtyage and sex matched participants were included in the study and further divided into two groups. In study group thirtyconfirmed cases of oral squamous cell carcinoma on pathologywere recruited. Oxidative stress markers were measured and statistically analyses done by using SPSS software version 25. The results showed increase levels of malondialdehyde, 8-hydroxy-2-deoxyguanosine, isoprostanes, interleukin-6 and tumor necrosis factor alpha as compared to the control groups (p= 0.023, 0.001, 0.041, 0.000 and 0.033 respectively). Oxidative stress markers are elevatedlevels of oxidative stress marked are found in patients of OSCC. That may lead to swift progression of disease and may increase mortality rate.