Open AccessNeurodevelopmental outcome in congenital diaphragmatic hernia: Evaluation, predictors and outcome
Author(s) -
Enrico Danzer
Publication year - 2014
Publication title -
world journal of clinical pediatrics
Language(s) - English
Resource type - Journals
ISSN - 2219-2808
DOI - 10.5409/wjcp.v3.i3.30
Subject(s) - congenital diaphragmatic hernia , medicine , pediatrics , intervention (counseling) , quality of life (healthcare) , medline , retrospective cohort study , diaphragmatic breathing , intensive care medicine , psychiatry , surgery , pathology , pregnancy , fetus , genetics , alternative medicine , nursing , political science , law , biology
To review the reported neurodevelopmental outcome of congenital diaphragmatic hernia (CDH) survivors, identify important predictors of developmental disabilities, and describe the pathophysiological mechanisms contributing to adverse outcome. A Medline search was performed for English-language articles cross-referencing CDH with pertinent search terms. Retrospective, prospective, and longitudinal follow-up studies were examined. The reference lists of identified articles were also searched. Neurodevelopmental dysfunction has been recognized as one of most common and potentially most disabling outcome of CDH. Intelligence appears to be in the low normal to mildly delayed range. Neuromotor dysfunction is common during early childhood. Behavioral problems, hearing impairment, and quality of life related issues are frequently encountered in older children and adolescence. Disease severity correlates with the degree of neurological dysfunction. Neurodevelopmental follow-up in CDH children should become standard of care to identify those who would benefit from early intervention services and improve neurological outcomes.