Open AccessSensitivity and specificity of a rapid diagnostic test for chronic Chagas disease at a referral center in Brazil - can it be included as a standard serological diagnostic test in the clinical practice of a referral center?
Author(s) -
Alejandro Marcel HasslocherMoreno,
Ingebourg Georg,
Luiz Henrique Conde Sangenis,
Mauro Felippe Felix Mediano
Publication year - 2021
Publication title -
microbes, infection and chemotherapy
Language(s) - English
Resource type - Journals
ISSN - 2789-4274
DOI - 10.54034/mic.e1236
Subject(s) - medicine , serology , chagas disease , diagnostic test , rapid diagnostic test , referral , disease , clinical practice , diagnostic accuracy , clinical diagnosis , immunology , pediatrics , physical therapy , antibody , family medicine
Chagas disease (CD) is a neglected tropical disease. In the chronic phase of CD, the diagnosis is essentially serologic. Conventional reactions are currently in use. More recently, the use of rapid diagnostic testing (RDT) is indicated when conventional techniques are not available. Objective: To evaluate the sensitivity and specificity of RDTs for chronic CD diagnosis. Methodology: Individuals under suspicion of CD were evaluated using ELISA, Chemiluminescence (ChLIA) and RDT tests. Results: The RDT showed 95.1% sensitivity and 96.7% specificity, respectively. Conclusion: The findings of the present study showed that RDT used in the diagnosis of CD at a referral center in Brazil were not able to detect all CD cases when compared to Elisa and ChLIA.