Open AccessLGI1 positive paraneoplastic limbic encephalitis: A case report of atypical presentation
Author(s) -
ChienChung Cheng,
Jia-Ying Sung,
Chih-Shan Huang
Publication year - 2021
Publication title -
neurology asia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.138
H-Index - 16
ISSN - 1823-6138
DOI - 10.54029/2021auz
Subject(s) - limbic encephalitis , medicine , encephalitis , temporal lobe , etiology , glioma , pathology , presentation (obstetrics) , epilepsy , immunology , surgery , cancer research , psychiatry , virus
Limbic encephalitis is a rare disorder mainly affecting the medial temporal lobe and is classically paraneoplastic. Autoimmune etiologies also exist, such as antibodies against leucine-rich glioma activated 1 (LGI1). Most cases of anti-LGI1 encephalitis are not associated with tumors. Subacute memory loss is the predominant feature, and most patients develop focal seizures, especially faciobrachial dystonic seizures (FBDSs). Immunotherapies usually show a good response, but are less effective in paraneoplastic cases. We report a case of steroid-responsive anti-LGI1 encephalitis with atypical presentations of sensory aphasia during relapse from rectal carcinoma, an atypical site.