Open AccessAre Dysregulated Inflammatory Responses to Commensal Bacteria Involved in the Pathogenesis of Hepatobiliary-Pancreatic Autoimmune Disease? An Analysis Using Mice Models of Primary Biliary Cirrhosis and Autoimmune Pancreatitis
Author(s) -
Naoko Yanagisawa,
Ikuko Haruta,
Ken Kikuchi,
Noriyuki Shibata,
Junji Yagi
Publication year - 2011
Publication title -
isrn gastroenterology
Language(s) - English
Resource type - Journals
eISSN - 2090-4401
pISSN - 2090-4398
DOI - 10.5402/2011/513514
Subject(s) - primary biliary cirrhosis , autoimmune pancreatitis , pathogenesis , medicine , autoimmune disease , immunology , pancreatitis , biliary cirrhosis , disease , primary sclerosing cholangitis , pathology , gastroenterology
The etiopathogenesis of many autoimmune disorders has not been identified. The aim of this paper is to focus on the involvement of bacterial exposure in the pathogenesis of primary biliary cirrhosis (PBC) and autoimmune pancreatitis (AIP), both of which are broadly categorized as autoimmune disorders involving hepatobiliary-pancreatic lesions. Avirulent and/or commensal bacteria, which may have important role(s) as initiating factors in the pathogenesis of autoimmune disorders such as PBC and AIP, will be emphasized.