Open AccessExploring the Protein Interactome Related to Hepatitis C Virus
Author(s) -
Shifa Tariq Ashraf,
Marriam Bakhtiar
Publication year - 2021
Publication title -
nust journal of natural sciences
Language(s) - English
Resource type - Journals
eISSN - 2710-222X
pISSN - 2072-4659
DOI - 10.53992/njns.v3i1.15
Subject(s) - interactome , hepatocellular carcinoma , hepatitis c virus , computational biology , biology , cirrhosis , interaction network , gene , virus , protein–protein interaction , liver disease , gene regulatory network , disease , virology , genetics , medicine , gene expression , pathology , biochemistry , gastroenterology
Hepatitis C virus (HCV) stands as a health problem experienced across the globe leading to chronic or acute liver diseases such as cirrhosis, hepatocellular carcinoma and various others. It is a complex disease with extensive genetic heterogeneity with little known about the interactions of complex intra- and intercellular processes. The evolving tools in the application of network science to identify diseases have paved a way for the study of complex diseases at system level. This study focuses on identifying the significant proteins and the biological regulatory pathways involved in Hepatitis C virus and performing topological analysis of the PPIs derived by the proteins encoded by the susceptible genes in order to look for the molecular connectivity between these pathways.icant proteins and the biological regulatory pathways involved in Hepatitis C virus and performing topological analysis of the PPIs derived by the proteins encoded by the susceptible genes in order to look for the molecular connectivity between these pathways.