Treatment of Dysmenorrhea with Physiological Modulators (A28): A Registry Study

Background: Dysmenorrhea is a diseases affecting about 45% of menstruating women (approximately between 45 to 95 % of females) during the time of menses and causing a reduction of the quality of life. Objective: To reduce the symptoms of dysmenorrhea using a natural Physiological Mosdulator (A 28) consisting of low dosages of calcium salts, Vitamin D, bioflavonoids, lycopene, and astaxanthin. Material and methods: Forty patients with severe dysmenorrhea were analyzed during two menstrual cycles: the first as baseline following a run-inn period, and the second during the treatment with A28. A simple VAS scale scoring the daily discomfort (from 0 =no discomfort to 6 =maximum discomfort) was used to measure the severity of the symptoms.The total score of first 3 days following the start of menses was calculated.The use of pain rescue cps during the two period was compared. Results: Thirty-eight cases completed the experience. Before treatment, the mean of total scores was 8.1±2.40, while after A28 it was reduced to 1.7± 1.39 (U Mann Whitney p< 0.01) . The mean of pain rescue cps used was respectively 6.1±1.21 and 0.5±1.15 before and after the A28 treatment (p <0.01). No side effects were reported. Conclusion: The use ofa combination of Physiological Modulators effectively decreased the daily discomfort due to dysmenorrhea.