Open AccessData on FTIR spectra of mixtures of sodium valproate (VPA) and histones H1 and H3
Author(s) -
Maria Luiza S. Mello,
Benedicto de Campos Vidal
Publication year - 2022
Publication title -
latin american data in science.
Language(s) - English
Resource type - Journals
ISSN - 2763-9290
DOI - 10.53805/lads.v1i3.36
Subject(s) - histone , valproic acid , epigenetics , chromatin , chemistry , fourier transform infrared spectroscopy , dna , biophysics , biochemistry , microbiology and biotechnology , biology , epilepsy , physics , neuroscience , gene , quantum mechanics
Valproic acid/sodium valproate (VPA), a drug primarily used for treatment of seizure disorders, is recognized as an efficient epigenetic agent, inducing inhibition of histone deacetylases, promoting changes in the methylation status of DNA and histones, and affecting chromatin structure. In addition to these epigenetic effects, molecular affinity of VPA for histone H1 has been proposed based on thermal denaturation, fluorescence spectroscopy and circular dichroism assays. VPA interactions with DNA and histones using Fourier transform infrared (FTIR) microspectroscopy and high-performance polarization microscopy that are not related to the effects promoted on epigenetic markers have been recently explored. Data in this article provide supplementary information for a better understanding of the resulting FTIR spectra for mixtures of VPA and histones H1 and H3 and of the potential effect of VPA directly on histones that has been reported in the literature.