Open AccessUpdate on Treatment and Prevention of Chronic Antibody Mediated Rejection in Renal Transplant Recipients
Author(s) -
Salman Tahir Shafi
Publication year - 2021
Publication title -
pakistan journal of kidney diseases
Language(s) - English
Resource type - Journals
eISSN - 2708-3020
pISSN - 2617-0329
DOI - 10.53778/pjkd40353
Subject(s) - medicine , immunology , antibody , complement dependent cytotoxicity , cytotoxicity , proteinuria , renal transplant , chronic renal failure , complement system , complement (music) , chronic renal disease , transplantation , kidney disease , antibody dependent cell mediated cytotoxicity , kidney , biology , monoclonal antibody , in vitro , biochemistry , phenotype , complementation , gene
Chronic antibody mediated rejection (AMR) is a major cause of allograft failure1,2. Chronic AMR clinically presents with proteinuria and gradual decline in renal function. The underlying mechanisms of AMR include both antibody mediated complement-dependent cytotoxicity, complement-independent cellular cytotoxicity and other mechanisms. The purpose of this review is to appraise recent literature on diagnosis, treatment and prevention of chronic AMR.