Open AccessMimicking human antidepressant activity in Swiss Albino Mice using Madhuca Longifolia
Author(s) -
Neha Munot,
Patil Suraj,
Abhinandan Patil,
Rai Neeta,
Kandekar Ujjwala,
Ghodake Shweta
Publication year - 2022
Publication title -
international journal of health sciences (ijhs) (en línea)
Language(s) - English
Resource type - Journals
eISSN - 2550-6978
pISSN - 2550-696X
DOI - 10.53730/ijhs.v6ns4.6411
Subject(s) - antidepressant , behavioural despair test , traditional medicine , reserpine , tail suspension test , animal models of depression , pharmacology , medicine , biology , hippocampus
The present study was evaluated to screen the antidepressant potential of Madhuca longifolia in different animal models like forced swim test (FST), tail suspension test(TST), reserpine induced hypothermia (RIH). Adult swiss albino mice weighing 25- 30 gm.Standard drug used in above study was Fluoxetine(10mg/kg,p.o). The antidepressant activity of Madhuca longifolia was compared to the standard drug. The model shows closely mimics symptoms & signs of human depression. The high dose of Madhuca longifolia showed extremely high significant values over standard drugs with a decrease in immobility and ptosis. The results obtained in the present study suggest that Madhuca longifolia proves to be a potential therapeutic drug for treating depression along with anti-inflammatory, anti-psoriatic and antioxidant activity.