Open AccessEvaluation of hepatoprotective effect of Withania somnifera and Rubia cordifolia against carbon tetrachloride induced hepatotoxicity in albino rats
Author(s) -
P.A Aboobecker Siddique,
Anand Gaur,
Anurag Bajpai,
Abhay John
Publication year - 2022
Publication title -
international journal of health sciences (ijhs) (en línea)
Language(s) - English
Resource type - Journals
eISSN - 2550-6978
pISSN - 2550-696X
DOI - 10.53730/ijhs.v6ns4.5693
Subject(s) - withania somnifera , carbon tetrachloride , ccl4 , acclimatization , saline , pharmacology , excretion , traditional medicine , medicine , chemistry , biology , botany , pathology , alternative medicine , organic chemistry
Liver is one of the largest gland of the body and the main site for intense metabolism and excretion. Liver is concerned with metabolism of endogenous as well as exogenous substances. “Withania somnifera” and “Rubia cordifolia” claim to have hepatoprotective action. Till now, no scientific study has been performed to evaluate such claims. This was an experiment study conducted on wistar rats, in Department of Pharmacology, Index Medical College. Healthy Albino wistar rats of either gender, weighing 150- 200g were obtained from CPCSEA approved Central Animal House. The selected rats were housed in polpropylene cages under controlled conditions of temperature (25 0C) and alternating periods of light and darkness of 12 hours each. The rats had free access to standard rat pellet diet and tap water ad libitum. After one week of acclimatization, the animals were rendered suitable for study. Pregnant female rats were not included in the study. ALT level in normal saline treated group was 29.5±3.35 IU/L. It was found to be significantly increased (p<0.001) with administration of CCl4 to 433.5±48.67 IU/L.