Open AccessStudy of anti-inflammatory activity of aqueous and methanolic extracts of fresh rhizome of Zingiber Officinale in Wistar rats
Author(s) -
Prathamesh V. Pakale,
Chitra C. Khanwelkar,
Smita Jadhav
Publication year - 2022
Publication title -
international journal of health sciences (ijhs) (en línea)
Language(s) - English
Resource type - Journals
eISSN - 2550-6978
pISSN - 2550-696X
DOI - 10.53730/ijhs.v6ns3.5982
Subject(s) - zingiber officinale , rhizome , anti inflammatory , traditional medicine , carrageenan , aqueous extract , chemistry , aspirin , pharmacology , medicine , biochemistry
To evaluate the anti-inflammatory activity of aqueous and methanolic extracts of fresh rhizome of plant Zingiber officinale: 1. To evaluate anti-inflammatory activity of all extracts in two doses and the standard drug in wistar rats by using Carrageenan induced paw edema method. 2. To compare anti-inflammatory activity of both extracts with that of standard drug. The study was conducted after animal ethics committee approval. Animals were divided into six groups. Control group received 0.2ml NS IP while test groups received aspirin (150mg/kg) , Aqueous extract of fresh rhizome of Z. officinale (100 and 200mg/kg) , Methanolic extract of fresh rhizome of Z. officinale (100 and 200 mg/kg). Acute model of inflammation consisting of carrageenan induced rat paw edema method was used to investigate anti-inflammatory activity of Ginger. The present study clearly showed significant anti-inflammatory activity of aqueous and methanolic extracts of fresh rhizome (p < 0.05) in acute model of inflammation when compared to control and its activity was comparable to aspirin at all time interval. Aqueous and methanolic extracts of gingiber officinale have significant anti‑inflammatory property.