Open AccessA randomized study of midazolam versus dexmedetomidine for premedication in children via intranasal mucosal atomization device
Author(s) -
Malini Mehta,
Rajsi Shah,
Ashish Tyagi,
V. Madhuri
Publication year - 2022
Publication title -
international journal of health sciences (ijhs) (en línea)
Language(s) - English
Resource type - Journals
eISSN - 2550-6978
pISSN - 2550-696X
DOI - 10.53730/ijhs.v6ns3.5702
Subject(s) - dexmedetomidine , premedication , midazolam , medicine , anesthesia , sedation , randomized controlled trial , sedative , surgery
Many drugs have been tried for premedication in children[1] amongst which midazolam and dexmedetomidine are commonly used and are reportedly safe and effective for usage during both separation as well as induction of anaesthesia. Hence, we planned to carry out a study of midazolam versus dexmedetomidine for premedication in children via intranasal Mucosal Atomization Device. To compare the efficacy of midazolam and dexmedetomidine as premedication in children of 2 to 6 years of age via intranasal Mucosal Atomization Device. This randomized study was done at Dhiraj hospital, Piparia, Vadodara, Gujarat on 60 children belonging to American Society of Anaesthesiologists (ASA) physical status I or II of age 2-6 years of either gender undergoing elective surgeries under general anaesthesia. Children were separated into: Group M - Midazolam 0.2 mg/kg (preservative free) Group D - Dexmedetomidine 1µg/kg. Drug was administered 30 minutes prior to surgery and following parameters were assessed: Acceptance of drug, Sedation Score, behaviour during parental separation and mask acceptance. Dexmedetomidine was statistically significantly better in aspect of drug acceptance, sedation after 30 minutes of drug administration, parental separation and mask acceptance than midazolam.