Open AccessDetermination of dutasteride in pure and tablet by flow injection system
Author(s) -
Yehya K. Al-Bayatie,
Yasmeen H. Muhamad,
Zainab M. Kareem,
Mohammed T. Khathi
Publication year - 2022
Publication title -
international journal of health sciences (ijhs) (en línea)
Language(s) - English
Resource type - Journals
eISSN - 2550-6978
pISSN - 2550-696X
DOI - 10.53730/ijhs.v6ns3.5260
Subject(s) - dutasteride , chloranil , acetonitrile , detection limit , relative standard deviation , chemistry , linearity , chromatography , correlation coefficient , analytical chemistry (journal) , materials science , mathematics , organic chemistry , medicine , statistics , physics , prostate , cancer , quantum mechanics
A new Spectrophotometric flaw injection method has been established for the determination of Dutasteride (DS) in Pure and pharmaceutical tablets preparations. The method was based on the interaction of Dutasteride, as an n-electron donor with Chloranil as a π-acceptor, in acetonitrile to give reddish orange colored Chloranil radical anion with absorption maxima at 525 nm. The linearity of this method was in the range of (0.9948-8.932) ug.ml' with a correlation coefficient of 0.9969, a relative standard deviation (RSD) 0.422 %, with detection limit of (0.420) ug.ml".