Open AccessSynthesis of Novel Quinazolin-4-one hybrids as potential antimicrobial agents
Author(s) -
Yogesh Kumar Lawaniya,
Pradeep Goyal
Publication year - 2022
Publication title -
international journal of health sciences (ijhs) (en línea)
Language(s) - English
Resource type - Journals
eISSN - 2550-6978
pISSN - 2550-696X
DOI - 10.53730/ijhs.v6ns2.6573
Subject(s) - antifungal , antimicrobial , anhydrous , combinatorial chemistry , chemistry , aryl , amide , carbon monoxide , palladium , catalysis , organic chemistry , microbiology and biotechnology , biology , alkyl
We have developed an effortless and extremely efficient procedure for the synthesis of quinazolin-4-one derivatives via palladium-catalyzed C-Ccoupling of aryl amide with isocyanides. The reactions are operationally simple and avoid using toxic carbon monoxide and acid chloride, which must be used in an anhydrous system. The structure of the novel compounds was confirmed based on spectral data. We also demonstrated the biological potential of these compounds as novel Antifungal Activity. Based on the MIC results, the most active is 3g.