Open Accessobservational study of oral clonidine as a pre-medicant for attenuation of hemodynamic responses to laryngoscopy and intubation
Author(s) -
Priya S. Kishnani,
Chaitali Shah,
Nilesh Shah,
Kirti Patel
Publication year - 2022
Publication title -
international journal of health sciences (ijhs) (en línea)
Language(s) - English
Resource type - Journals
eISSN - 2550-6978
pISSN - 2550-696X
DOI - 10.53730/ijhs.v6ns2.6303
Subject(s) - laryngoscopy , clonidine , medicine , anesthesia , intubation , premedication , hemodynamics , blood pressure , heart rate , tracheal intubation , placebo , alternative medicine , pathology
Endo-tracheal intubation causes noxious stimulation to hemodynamics. In search for an ideal agent to attenuate this response, many drugs have been used. Clonidine is an α2-agonist and have been used as a premedicant to attenuate hemodynamic response. Aim: To observe the attenuating effect of oral clonidine on hemodynamic response to laryngoscopy and tracheal intubation. Setting and Design: This was an observational comparative study. Material and Method: 44 patients of either sex, aged of 18- 65 years,ASA I and II undergoing for elective surgery under general anesthesia were enrolled. They were randomly allocated to receive oral clonidine (100 mcg) or placebo (vitamin B complex) as premedication 60- 90 min before induction. Heart rate, systolic blood pressure, diastolic blood pressure and mean arterial pressure were recorded before, immediately after and then 1, 3 min and thereafter every 5 min after intubation until 30 min. Result:A statistically significant difference was observed in heart rate, systolic blood pressures and means arterial pressure and was significantly higher in Placebo group following intubation. Conclusion:Oral clonidine 100mcg in preanesthetic period, provide more haemodynamic stability and attenuate the stress response to laryngoscopy and intubation.