Open AccessViral load and B-catenin level correlation study in patients with chronic hepatitis B virus
Author(s) -
Ahmed Mohammed,
Sura A. Abdulsattar,
Sabeha Al-bayati
Publication year - 2022
Publication title -
international journal of health sciences (ijhs) (en línea)
Language(s) - English
Resource type - Journals
eISSN - 2550-6978
pISSN - 2550-696X
DOI - 10.53730/ijhs.v6ns2.5815
Subject(s) - medicine , hbx , viral load , viral hepatitis , hepatitis b virus , chronic hepatitis , immunology , hepatitis b , hepatitis , virus , viral replication , virology
Hepatitis a general term which refers to inflammation of the liver. It may result from various causes, both infectious ( viral, bacterial, fungal, and parasitic) and noninfectious (alcohol, drugs, autoimmune diseases, and metabolic diseases). The hepatitis B X protein (HBx) plays a role in the epigenetic regulation of HBV replication. Real-time PCR has catalysed wider acceptance of PCR because it is more rapid, sensitive and reproducible, while the risk of carryover contamination is minimised. The present study is a case-control study design comprise a total of 58 patient with hepatitis B of which 29 patients were with chronic infection and additional 29 patient with chronic hepatitis, and 30 apparently healthy control subjects. In the current study, fifty - eight diagnosed hepatitis B virus patients were enrolled. The correlations of study biomarkers with viral load in the (chronic hepatitis group) of HBV patients. B-catenin showed a significant positive correlation with viral load in chronic hepatitis group (r = 0.387, p = 0.038).