Open AccessComparative study on hepatoprotective activity of Pongamia pinnata (PP) & Annona squamosa (AS) leaf extracts against anti-tubercular drugs (isoniazid & rifampin) induced hepatotoxicity in rats
Author(s) -
Samba Siva Raju Derangula,
N. S. Muthiah,
B. V. Surendra,
K. Somasekhar Reddy,
H. S. Somashekar,
E. Sukumar,
Krishnananda Prabhu
Publication year - 2022
Publication title -
international journal of health sciences (ijhs) (en línea)
Language(s) - English
Resource type - Journals
eISSN - 2550-6978
pISSN - 2550-696X
DOI - 10.53730/ijhs.v6ns2.5174
Subject(s) - annona squamosa , pongamia , traditional medicine , annona , transaminase , superoxide dismutase , pharmacology , medicine , chemistry , biochemistry , annonaceae , enzyme , biodiesel , catalysis
Objectives: - The goal of this study is to compare the effects of Pongamia Pinnata and Annona Squamosa on anti-tubercular medicines-induced hepatotoxicity in rats. Materials and Procedures: - In rats, hepatotoxicity was caused by administering a suspension of isoniazid and rifampin orally for 21 days. Pongamia Pinnata and Annona Squamosa, as well as anti-tubercular medicines, were given to the treatment groups. Biochemical & histological criteria were used to measure liver destruction. Results: - The use of Pongamia Pinnata and Annona Squamosa in combination with anti-tubercular medicines dramatically reduced Serum Glutamate Pyruvic Transaminase (SGPT), Serum Glutamate Oxaloacetic Transaminase (SGOT)& tissue malondialdehyde (MDA) levels. Inflammation, degeneration, and necrotic alterations in hepatocytes were reduced. Pongamia Pinnata also reduced a drop in blood Superoxide Dismutase (SOD) when compared to a control group getting only anti-tubercular medicines. Pongamia Pinnata, on the other hand, had no statistically significant effects when compared to Annona Squamosa and silymarin. Conclusion: - Annona Squamosa was found to be an effective hepatoprotective agent in rats, as it considerably reduced the hepatotoxic damage caused by anti-tubercular medicines. However, when the effects of Pongamia Pinnata & Annona Squamosa or silymarin were compared, there was no statistically significant difference.