Role of NLRP3 in patients infected with Toxoplasma gondii parasite

The study was conducted on 350 aborted women and 30 healthy women who have visited AL-Zahra maternity and paediatrics hospital in AL-Najaf province from November from August to January 2022. This study was designed to determine the effects of T. gondii infection on some parameters such as NLRP3, IL-18, IL-1β  and TNF-α , The results showed a significant elevation (P<0.001) in serum concentration of The current study revealed that serum concentration of NLRP3 (ng/ml), IL-18 (pg/ml), IL-1β (pg/ml) and TNF-α (pg/ml) in patients infected with Toxoplasma gondii were significant increase (P  (46. 21642 ± 0.524 ng/ml), (474. 12338± 0.906 pg/ml), (15. 41450± 0.218 pg/ml), (25. 4145065284± 0.218232 pg/ml)  in compared to the control group (9.701792 ± 0.555 ng/ml), (97.107565 ± 0. 700 pg/ml), (4.129558 ± 0. 190 pg/ml), (6.45839 ± 0. 220 pg/ml). The current study has concluded that the infection with T. gondii affects the body's immunity by NLRP3, IL-18, IL-1β and TNF-α.