Open AccessBiomarkers of acute kidney injury
Author(s) -
Sachin Yedve,
Sachin Damke
Publication year - 2022
Publication title -
international journal of health sciences (ijhs) (en línea)
Language(s) - English
Resource type - Journals
eISSN - 2550-6978
pISSN - 2550-696X
DOI - 10.53730/ijhs.v6ns1.5832
Subject(s) - acute kidney injury , creatinine , medicine , biomarker , intensive care medicine , blood urea nitrogen , disease , urine , kidney disease , stage (stratigraphy) , bioinformatics , biology , paleontology , biochemistry
AKI is a common condition with a high risk of death. This condition can be identified easily and treated early with a good outcome. The standard metrics used to define AKI like serum creatinine blood urea nitrogen are insensitive and nonspecific and change significantly only after huge injury which can lead to delay in diagnosis and treatment. The kidney is capable in withstanding injuries for an prolonged period. The lacking of knowledge of biomarkers has led to an increase in morbidity. As children progress to higher stages of AKI the risk and morbidity increase. The urine has yielded promising markers for early detection of AKI and also helps in anticipation. These markers help in the identification of the mechanism of injury, assessment of the site, and severity of the injury. One or more of these biomarkers, singly or in combination will help in diagnosis, intervention, and progression of the disease. The use of creatinine as a marker of AKI has various limitations, like variation in its secretion and extrarenal excretion. Toxin-mediated AKI may be amenable to biomarker detection given the direct tubular injury Imparted by various toxins.