Open AccessElevated serum levels of interleukin -22 and interleukin-23 in pediatric asthma
Author(s) -
Baneen Ahmed Jabbar,
Abeer Thaher Naji AL-Hasnawi,
Aqeel Mahdi Hussein,
Haidar Abdul Amir Najim Abood,
Jalal Ali Ashour
Publication year - 2022
Publication title -
international journal of health sciences (ijhs) (en línea)
Language(s) - English
Resource type - Journals
eISSN - 2550-6978
pISSN - 2550-696X
DOI - 10.53730/ijhs.v6ns1.5690
Subject(s) - medicine , asthma , outpatient clinic , interleukin 5 , case control study , interleukin , immunology , gastroenterology , cytokine
Background: There are few studies had addressed the association between serum levels of Interleukin -22 and Interleukin-23 with severity of asthma, this study aims to evaluate whether elevated IL-22 and IL-23 serum levels is related to the severity of asthma. Methods: This study is a case-control study that included 60 asthmatic children (35 male and 25 female) as the patients group age ranged between 4 months to 14 years old, and 60 non-asthmatic (32 male and 28 female) age-matched patients group attending the outpatient clinic were recruited as control group. Serum levels of IL-22 and IL-23 was measured by sandwich ELISA using ELISA kits. Results: The results of this study have shown an elevated serum level of IL-23 in patients group compared with control group with significant (p= 0.008) and there was no significant difference between patients and control regarding IL-22 serum level (p = 0.721) in asthmatic children. Conclusion: According to the current study the serum level of IL-23 showing a significant association with the asthma severity in children.