Open AccessDetermination of deferasirox (anti-thalassemia drug) in serum and urine: cyclic voltammetry study
Author(s) -
Fatima Hamza M. baker,
Hiba Ali Numan,
Muthana Saleh Mashkour
Publication year - 2022
Publication title -
international journal of health sciences (ijhs) (en línea)
Language(s) - English
Resource type - Journals
eISSN - 2550-6978
pISSN - 2550-696X
DOI - 10.53730/ijhs.v6ns1.5653
Subject(s) - deferasirox , cyclic voltammetry , chemistry , voltammetry , analytical chemistry (journal) , urine , electrochemistry , electrode , chromatography , thalassemia , medicine , biochemistry
The purpose of this project is to examine cyclic voltammetry (CV) analytical technique for anti_thalassemia drug of deferasirox by modified multi-walled carbon nanotubes (MWCNTs) on glassy carbon electrod (GCE) was described. The electrochemical performance of deferasirox was studied by cyclic voltammetry technique. The ability of the electrode for the determination of deferasirox under Optimize condition in pH 13.8~14, scan rate 100mv/s, temperature 30 0C and interference that have been studied. Where found the results that calibration curve of deferasirox was linear in the concentrations 13.4×10-4-2.6×10-2 M, its detection limit was 8.46×10-11 M and LOQ was 2.82×10-10 M. The enthalpy ∆H was calculated to be (6.736 kJ. mol-1), and the entropy can be calculated to be (213.8 J. K‐1 mol‐1). The area of electrode was calculated to be 0.314 cm2 and also the diffusion coefficient was 3.154×10-4 cm2sec-1. RSD% for bulk and form was less than 0.3% while serum and urine less than 2.5% and recovery in all close to 100.1%. The voltammogram for deferasirox give irreversible process with diffusion– controlled process. Finally, this technique has been applied for deferasirox on pharmaceutical formulations and biological samples (serum and urine).