Analysis of biochemical and immune biomarker abnormalities associated with severe illness and mortality in COVID -19 disease

Coronavirus Disease 2019 (COVID-19), a new form of respiratory and systemic disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARSCoV2). The inflammation induced by the SARS CoV-2 virus in the host leads to elevation of multiple inflammatory parameters. A raise in PCT, IL-6 and CRP denotes the intensity of inflammation in COVID-19 patients. Similarly, D-DIMER and FIBRINOGEN marks the aberration in the coagulation pathways in COVID-19 patients.COVID-19 positive patients aged between 18 and 65 years were recruited for the study after written informed consent. To confirm all cases according to nucleic acid real time–polymerase chain reaction (RT-PCR) tests. In the present study, a total of 200 COVID-19 patients were assessed. Out of them 100 (50%) were severe cases of COVID-19 and 100 (50%) were non-severe cases of COVID-19. On comparison of various biochemical and immune biomarkers, the severe COVID-19 patients demonstrated significantly higher levels of all biomarkers when compared with non-severe group.