Open AccessEffectiveness of glucose-insulin–potassium infusion for myocardial protection in non-diabetic patients during adult cardiac surgery
Author(s) -
Attiya Hameed Khan,
Hafsa Rasool,
Hammad Ahmed,
Khawaja Ahsen Faheem,
Aamir Naveed,
Shahid Hussain
Publication year - 2020
Publication title -
journal of bashir institute of health sciences
Language(s) - English
Resource type - Journals
eISSN - 2789-1151
pISSN - 2789-1143
DOI - 10.53576/bashir.01.01.0016
Subject(s) - medicine , cardiopulmonary bypass , insulin , observational study , cardiac surgery , diabetes mellitus , anesthesia , surgery , endocrinology
Background: Glucose-insulin-potassium (GIK) infusion is most commonly used in diabetic patients during cardiopulmonary bypass. Many studies suggest that the use of GIK infusion has beneficial outcomes mainly in myocardial protection, as myocardial protection is the main goal of Perfusionist during bypass surgery. In Pakistan, GIK is used normally in the diabetic patient as it has a good effect on insulin maintenance. Most surgeons use GIK in diabetic patients but many of the studies suggest that it has good post-op outcomes especially in myocardial protection. Method: This was an observational cross-sectional study conducted for 6 months, from November 2019 to April 2020 at the Pakistan Institute of medical sciences department of Cardiac surgery. Ethical approval was taken from the hospital ethical committee. It was consisting of 80 patients, 40 from group A (GIK infused) and 40 from group B (GIK non-infused) by using the Non-probability convenient sampling technique. Data was collected through pre-structured Performa. Results: In the early postoperative period, peak CKMB levels were high in the Non-GIK group (62.7375± 19.75393IU/L) versus (54.0005±11.41493IU/L) in the GIK group (p-value 0.000). Mean ventilation time in the GIK group was (10.85 ±6.302) hours versus (12.15 ±7.814) hours in the non-GIK group (p 0.001). Conclusion: Glucose-insulin-potassium (GIK) infusion has a beneficial role in myocardial protection and is associated with better post-operative outcomes without increasing the risk of non-cardiac complications.