Open AccessDual Role of RNase A and Metosartan: An Examination in invitro & invivo Condition
Author(s) -
Eswari Beeram
Publication year - 2019
Publication title -
journal of advance research in pharmacy and biological science
Language(s) - English
Resource type - Journals
ISSN - 2208-2360
DOI - 10.53555/nnpbs.v5i5.742
Subject(s) - rnase p , sperm , in vivo , telmisartan , mitochondrion , in vitro , chemistry , metoprolol , andrology , microbiology and biotechnology , biology , biochemistry , medicine , endocrinology , rna , genetics , gene , blood pressure
Metosartan consists of two components Metoprolol and telmisartan. Telmisartan inhibits RNase A in rat testes by uncompetitive inhibition where as Metoprolol forms DNA adducts and reduces sperm count. Metosartan decreases testes viability and sperm count was found to be high in metosartan treated rats compared to Metosartan +RNase A group. RNase A induces Netosis in both invivo and invitro condition in both RNase treated group and as well as RNase A+ Metosartan. Deep cold storage of mitochondria induces expression of cyt P450gene in testes mitochondria but not in sperm.