Open AccessNevirapine induced Stevens Johnson syndrome
Author(s) -
Himani Prajapati,
Neetu Bala,
Dinesh Kansal
Publication year - 2020
Publication title -
journal of pharmacovigilance and drug research
Language(s) - English
Resource type - Journals
ISSN - 2582-7235
DOI - 10.53411/jpadr.2020.1.2.6
Subject(s) - nevirapine , efavirenz , medicine , rash , regimen , adverse effect , lamivudine , dermatology , pediatrics , human immunodeficiency virus (hiv) , surgery , antiretroviral therapy , virology , viral load , hepatitis b virus , virus
Severe and life-threatening SJS is more common with nevirapine than with other NNRTIs
Case presentation: A 56-year-old male patient presented with a complaint of lesions all over the body with a burning sensation for 4 days. He was on an ART regimen, containing zidovudine, lamivudine, and efavirenz combination for 4 years. But patient accidentally started nevirapine and after 10 days he developed maculopapular lesions which were diagnosed as SJS syndrome. There was a history of rash with nevirapine when ART was started initially in 2012. This incident of an adverse event could be assigned a term "probable" according to the WHO-UMC scale for causality assessment as the re-challenge was found positive.
Conclusion: Physicians and patients must be aware of this adverse effect on early diagnosis and treatment.