Open AccessA newly synthetic compound of Ibuprofen and Gabapentin as a novel analgesic and anti-inflammatory therapeutic agent: A pharmacological study in rats’ experimental models
Author(s) -
Manal A. Ibrahim,
Hiba Najeh Al-Saad,
Ahmed H. Al-Darraji,
Monther F. Mahdi
Publication year - 2021
Publication title -
journal of emergency medicine, trauma and acute care
Language(s) - English
Resource type - Journals
eISSN - 1999-7094
pISSN - 1999-7086
DOI - 10.5339/jemtac.2021.24
Subject(s) - ibuprofen , analgesic , gabapentin , pharmacology , medicine , flurbiprofen , anti inflammatory , edema , carrageenan , anesthesia , surgery , alternative medicine , pathology
Objective: Inflammation and pain are normally present concomitantly, which requires using a combination of anti-inflammatory and pain killer medications. This could potentially decrease patient adherence to such combinations. Therefore, there is an urgent need to develop combinations of anti-inflammatory and analgesic therapies. This study is designed to evaluate the analgesic and anti-inflammatory activities of a newly synthetic compound of ibuprofen and gabapentin. Method: The study protocol includes two stages. The first stage: the evaluation of the analgesic effectiveness of tested compounds via using hot plate and acetic acid induced-writhing tests. The second stage: the investigation of the anti-inflammatory activity via using dextran induced- peritonitis, cotton pelt induced- granulomas, and formalin induced- paw edema analyses. Rats were randomly divided into four groups (six rats in each group): Group A (control): rats were orally treated with vehicle (propylene glycol 50 % v/v); Group B: rats were orally treated with ibuprofen (10 mg/ kg); Group C: rats were orally treated with gabapentin (200 mg/ kg); and Group D: rats were orally treated with the synthetic compound (ibuprofen-gabapentin) in dose equivalent to 10 mg/ kg ibuprofen and 200 mg/kg gabapentin. Result: It was found that the newly synthesized compound of ibuprofen and gabapentin has significantly reduced the pain in comparison with control groups. Additionally, this compound has significant anti-inflammatory properties compared to medications admitted to the control group as well. Conclusion: The newly synthesized compound (ibuprofen-gabapentin) demonstrates remarkable analgesic and anti-inflammatory activities in comparison with the conventional compounds.