Open AccessNaNog: A pluripotency homeobox (master) molecule
Author(s) -
Mona Allouba,
Ahmed ElGuindy,
Navaneethakrishnan Krishnamoorthy,
Magdi H. Yacoub,
Yasmine Aguib
Publication year - 2015
Publication title -
global cardiology science and practice
Language(s) - English
Resource type - Journals
ISSN - 2305-7823
DOI - 10.5339/gcsp.2015.36
Subject(s) - homeobox protein nanog , rex1 , homeobox , microbiology and biotechnology , biology , stem cell , embryonic stem cell , cellular differentiation , nanog homeobox protein , cell potency , induced pluripotent stem cell , transcription factor , genetics , gene
One of the most intriguing aspects of cell biology is the state of pluripotency, where the cell is capable of self-renewal for as many times as deemed necessary , then at a specified time can differentiate into any type of cell. This fundamental process is required during organogenesis in foetal life and importantly during tissue repair in health and disease. Pluripotency is very tightly regulated, as any dysregulation can result in congenital defects, inability to repair damage, or cancer. Fuelled by the relatively recent interest in stem cell biology and tissue regeneration, the molecules implicated in regulating pluripotency have been the subject of extensive research. One of the important molecules involved in pluripotency, is NaNog, the subject of this article